In modern surgery, efficiently managing perioperative bleeding is crucial. Uncontrolled surgical bleeding poses significant risks to patient health and leads to substantial clinical and healthcare resource burdens. This challenge is particularly pronounced with an aging population and the rising prevalence of comorbidities and anticoagulant use. To address these issues, topical hemostatic agents have emerged as vital tools, promoting hemostasis where conventional methods fall short. These agents vary widely in properties, mode of action, ease of use, safety, and cost. Their selection often depends on the specific surgical scenario, bleeding situation, and patient’s health status.

Exploring Topical Hemostatic Agents

The current array of topical hemostatic agents comprises several types, each designed to meet different needs in the surgical setting:

Mechanical Agents: These are regarded as the simplest, safest, and most cost-effective. They offer a structural framework for hemostasis and are particularly useful in providing immediate bleeding control.

Active Agents: These utilize human, bovine, or recombinant thrombin. They actively engage the clotting process, making them effective in more challenging bleeding scenarios where mechanical agents might not suffice.

Gelatin-Thrombin Matrix Agents (Flowables): These combine gelatin and thrombin to provide a more adaptable solution that can conform to irregular wound surfaces, enhancing the hemostatic effect.

Sealants: Made from human fibrinogen or (semi)synthetic compounds, sealants form a fibrin clot that helps stop bleeding and can also promote tissue healing.

Among these, absorbable hemostatic powders stand out as revolutionary products designed to optimize surgical outcomes. Powdered hemostats are especially advantageous for their ease of use and efficacy in controlling continuous oozing bleeding of mild to moderate intensity over large surfaces [1, 2]. Their versatility and effectiveness make them an essential component in the surgical toolkit.

The Game-Changer: Surgi-ORC® Powder

Aegis Lifesciences is pleased to introduce Surgi-ORC® powder, an absorbable hemostat made from natural, plant-based oxidized regenerated cellulose, providing an effective solution for bleeding control.Surgi-ORC® Powder, in particular, is a natural, plant-based absorbable hemostat made from oxidized regenerated cellulose. It is specifically designed for faster control of continuous bleeding across broad surfaces and is suitable for both open and laparoscopic procedures.

Imagine a powder prefilled in a bellow bottle/applicator, ready to dispense directly onto a target bleeding site. Surgi-ORC® Powder is white with a pale yellow color and has a faint, caramel-like aroma. It effectively controls capillary, venous, and smallarterial haemorrhage and is fully absorbable. Surgi-ORC® Powder achieves hemostasis faster than other variants of Surgi-ORC® products.

Why Choose Surgi-ORC® Powder?

Composition and safety: Made from oxidized regenerated cellulose, Surgi-ORC® Powder ensures biocompatibility and safety. Being a natural, plant-based absorbable haemostat, it contains no animal-origin or collagen additives, making it suitable for patients with allergies or sensitivities.

Ease of application: Versatility is key. Surgi-ORC® Powder can be applied dry, directly onto bleeding areas or organs, making it suitable for various surgical procedures.

Rapid haemostasis: Time is of the essence in surgery. Surgi-ORC® Powder stops bleeding within minutes, which is crucial for complex surgeries to prevent complications.

Absorbable and biocompatible: Fully absorbable with minimal tissue reaction, Surgi-ORC® Powder reduces the risk of post-operative complications.

Antibacterial properties: The low pH of Surgi-ORC® Powder provides an antibacterial effect, reducing the risk of post-operative infections.

Convenience: Stored at room temperature and ready-to-use without any preparation, Surgi-ORC® Powder enhances surgical efficiency.

Durability in hemostasis: Surgi-ORC® Powder is designed to maintain hemostasis even under irrigation, ensuring stability during surgical procedures.

Mechanism of action

When Surgi-ORC® Powder comes into contact with blood, it forms a brownish or black gelatinous mass. This mass acts as a physical matrix to which platelets can adhere. As platelet aggregation occurs and a platelet-fibrin plug forms, the swelling material generates pressure on the surrounding tissue, contributing to haemostasis. Excess haemostat can be removed by irrigation with sterile water or saline solution after bleeding has stopped without disturbing the clot.

Mechanism of action

Surgi-ORC® powder Usage area

Surgi-ORC® powder Usage area

Simple, Fast, and Safe Application

Applying Surgi-ORC® Powder is straightforward. Due to its structure and penetrating ability, it may not require manual compression, making it optimal for minimally invasive procedures or open surgeries where manual compression is difficult to achieve.

Simple, Fast, and Safe ApplicationConclusion

Surgi-ORC® Powder represents a paradigm shift in surgical hemostasis, offering surgeons a reliable and efficient solution to manage perioperative bleeding. With its exceptional performance, user-friendly attributes, and demonstrated efficacy, Surgi-ORC® Powder is set to redefine standards in perioperative bleeding management, ensuring safer and more efficient surgical outcomes for patients worldwide.

References

[1] MacDonald MH, Tasse L, Wang D, Zhang G, De Leon H, Kocharian R. Evaluation of the hemostatic efficacy of two powdered topical absorbable hemostats using a porcine liver abrasion model of mild to moderate bleeding. Journal of Investigative Surgery. 2021 Nov 1;34(11):1198-206.https://doi.org/10.1080/08941939.2020.1792007

[2] Singh RK, Baumgartner B, Mantei JR, Parreno RN, Sanders PJ, Lewis KM, Barry JJ. Hemostatic comparison of a polysaccharide powder and a gelatin powder. Journal of Investigative Surgery. 2018 Feb 8.https://doi.org/10.1080/08941939.2017.1423421